Foot originated the famous trolley problem (in an essay called "The Problem of Abortion and the Doctrine of the Double Effect"). In the hypothetical, a runaway trolley continuing along the rails will hit 5 people who are working on the track. Should you actively divert the trolley onto a track where it will proceed to hit just one person? If you say yes, then should we favor killing a person to get 5 organs that can be used to save 5 lives?
Here's a PDF of the essay.